Acthar Gel HP Injection is a medicine used to treat the symptoms of Nephrotic Syndrome, Acute Exacerbations of Multiple Sclerosis and Verification of Adrenal Responsiveness. HP Acthar Gel may be used alone or with other medications.

What is Acthar Gel HP Injection

Acthar Gel HP Injection is a hormone that is used to treat many different conditions such as multiple sclerosis, psoriatic or rheumatoid arthritis, ankylosing spondylitis, lupus, severe allergic reactions, breathing disorders, and inflammatory conditions of the eyes.

Acthar Gel is also used to treat infantile spasms in children younger than 2 years old.

Acthar Injection can reduce the symptoms of many disorders, but it is not a cure for these conditions. This medicine is also not expected to slow the progress of any disease.

Acthar Injection may also be used for purposes not listed in this medication guide.


You should not use Acthar Injection if you have a fungal infection, herpes infection of the eyes, uncontrolled high blood pressure, scleroderma, osteoporosis, adrenal insufficiency (Addison’s disease), a past or present stomach ulcer, congestive heart failure, recent surgery, if you are allergic to pork proteins, or if you are scheduled to receive a vaccine.

Before taking Acthar Gel

You should not use Acthar HP Injection if you are allergic to it, or if you have:

  • a fungal infection anywhere in your body;
  • herpes infection of the eyes;
  • untreated or uncontrolled high blood pressure;
  • scleroderma;
  • osteoporosis;
  • adrenal insufficiency (Addison’s disease);
  • a past or present stomach ulcer;
  • congestive heart failure;
  • if you are allergic to pork proteins;
  • if you have recently had surgery; or
  • if you are scheduled to receive a vaccine.

Acthar Injection can worsen an infection you already have, or reactivate an infection you recently had. Before using Acthar Gel HP tell your doctor about any illness or infection you have had within the past several weeks.

Acthar Gel Injection should not be used in a child younger than 2 who has an infection that was passed from the mother during pregnancy or childbirth.

Tell your doctor if you have ever had:

  • high blood pressure, heart problems;
  • liver disease (such as cirrhosis);
  • kidney disease;
  • a thyroid disorder;
  • diabetes;
  • tuberculosis;
  • a muscle disorder such as myasthenia gravis;
  • glaucoma or cataracts;
  • depression or mental illness;
  • a stomach or intestinal disorder; or
  • a condition for which you take a diuretic or “water pill.”

Acthar Gel Injection may harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

You should not breastfeed while using Acthar Gel HP Injection 80 units/ml.

Do not give this medicine to a child without medical advice.

How is Acthar Gel Injection given

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Acthar Gel HP injection is injected into a muscle or under the skin. A healthcare provider may teach you how to properly use the medication by yourself.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don’t understand all instructions. Prepare an injection only when you are ready to give it.

Your dose needs may change during times of stress, serious illness, surgery or medical emergency. Tell your doctor if any of these situations affect you. Do not change your dose or dosing schedule without your doctor’s advice.

Acthar Gel HP Injection doses are based on body surface area (height and weight). Your dose needs may change if you gain or lose weight or if you are still growing.

In some people, Acthar Gel HP 80 units/ml can trigger an immune response to the medicine, making it less effective. Call your doctor if your condition gets worse or if it seems like this medicine does not work as well.

If you use this medicine long-term, you may need frequent medical tests, including bone scans to check for osteoporosis.

You should not stop using Acthar Gel Injection suddenly. Follow your doctor’s instructions about tapering your dose.

Store in the refrigerator. Take the medication out of the refrigerator and allow it to reach room temperature before preparing your dose.

Use a needle and syringe only once and then place them in a puncture-proof “sharps” container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.


Acthar Gel HP Injection

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